To get to Picayune, Mississippi...
| From New Orleans, LA, to Picayune, MS | |
| Direction | Distance |
| 1: Go Northeast on I-10 to I-59 | 36.8 miles |
| 2: Go Northeast on I-59 to Mississippi | 12.3 miles |
| 3: Go Northeast on I-59 to Picayune | 4.8 miles |
| From Baton Rouge, LA, to Picayune, MS | |
| Direction | Distance |
| 1: Go Southwest on I-110 to I-10 | 2.1 miles |
| 2: Go East on I-10 to I-12 | 5.5 miles |
| 3: Go East on I-12 to I-59 | 87.9 miles |
| 4: Go Northeast on I-59 to Mississippi | 12.3 miles |
| 5: Go Northeast on I-59 to Picayune | 4.8 miles |
| From Mobile, AL, to Picayune, MS | |
| Direction | Distance |
| 1: Go West on US 45 to I-10 | 0.8 miles |
| 2: Go Southwest on I-10 to Mississippi | 26.4 miles |
| 3: Go West on I-10 to State Rte 607 | 74.3 miles |
| 4: Go Northwest on State Rte 607 to I-59 | 11.5 miles |
| 5: Go Northeast on I-59 to Picayune | 3.8 miles |
| From Houston, TX, to Picayune, MS | |
| Direction | Distance |
| 1: Go East on I-10 to Louisiana | 111.0 miles |
| 2: Go East on I-10 to I-12 | 165.3 miles |
| 3: Go East on I-12 to I-59 | 87.9 miles |
| 4: Go Northeast on I-59 to Mississippi | 12.3 miles |
| 5: Go Northeast on I-59 to Picayune | 4.8 miles |
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